The Position

This position offers a unique opportunity to play a pivotal role in advancing the clinical development of Trontinemab, the first anti-amyloid antibody in trials to use brain-shuttle technology to treat Alzheimer’s disease.

In this role, the (Lead) Clinical Director will:

• Lead the clinical development strategy for one or more late-stage (Phase II–III) trials in Alzheimer’s disease
  
• Drive clinical trial design and execution, ensuring scientific rigor, ethical integrity, and clear regulatory alignment
  
• Provide medical monitoring for ongoing studies and ensure patient safety and data quality
  
• Collaborate with cross-functional teams including regulatory, clinical operations, safety, biomarkers, biostats, and early research
  
• Mentor and coach Clinical Scientists within the team
  
• Engage with external stakeholders such as advisory boards, key investigators, and health authorities
  
• Contribute to scientific publications and lead Roche’s presence in neurology through key conferences and community engagement
  
• Provide clinical input to earlier-stage programs to strengthen Roche’s neuroscience pipeline
  
  
  

Who Roche is looking for:

The ideal candidate is a mission-driven medical leader who combines scientific expertise with strategic thinking. The requirements include:

• An MD or MD/PhD, with clinical training in neurology or dementia, with deep expertise in Alzheimer’s disease
  
• Solid clinical research experience, including leadership in trial design and execution (preferably in the pharmaceutical industry)
  
• A solid understanding of the drug development lifecycle, from early-phase studies to post-marketing
  
• A proven track record of scientific impact, demonstrated through publications, presentations, or advisory contributions
  
• Exceptional communication skills and the ability to influence across a matrixed, cross-functional environment
  
• A passion for innovation and collaborative problem-solving, always with the patient at the centre

About Roche:

A healthier future drives Roche to innovate. Together, more than 100,000 employees across the globe are dedicated to advancing science, ensuring everyone has access to healthcare today and for generations to come. These efforts result in more than 26 million people treated with Roche’s medicines and over 30 billion tests conducted using Roche Diagnostics products. Roche empowers its people to explore new possibilities, foster creativity, and keep ambitions high, to deliver life-changing healthcare solutions that make a global impact.

Application

Click here